Protein Details: Protein orai-3

Protein ID

ICDB_Pro_1456

Protein Name

Protein orai-3

Gene Name

ORAI3; TMEM142C

Organism

Homo sapiens (Human)

Length

295 amino acids

AlphaFoldDB

AF-Q9BRQ5-F1-model_v4.pdb

Function

Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor; STIM1.

Sequence

MKGGEGDAGEQAPLNPEGESPAGSATYREFVHRGYLDLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLESDHEYPPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGFSTALGTFLFLAEVVLVGWVKFVPIGAPLDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSASAAPSQAEPACPPRQACGGGGAHGPGWQAAMASTAIMVPVGLVFVAFALHFYRSLVAHKTDRYKQELEELNRLQGELQAV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Acrofacial Dysostosis;Cincinnati Type and Anemia;Congenital Dyserythropoietic;Type Iv

Location

Expressed in both naive and effector T helper cells with higher levels in effector cells

DOI ID

10.1101/gr.2596504; 10.1038/nature04702; 10.1038/ncb2045; 10.1126/scisignal.2000672

RefSeq

NP_689501.1